Publications
Selected Journal Articles

  • Johnson, PJ, Tatara, A, Shiu, A, Sakiyama-Elbert, SE. Controlled release of neurotrophin-3 and platelet derived growth factor from fibrin scaffolds containing neural progenitor cells enhances survival and differentiation into neurons in a subacute model of SCI.  Cell Transplantation (in press) 2009.  Full text.

  • Johnson, PJ, Parker, SR, Sakiyama-Elbert, SE.  Controlled release of neurotrophin-3 from fibrin-based tissue engineering scaffolds enhances neural fiber sprouting following subacute spinal cord injury.  Biotechnology and Bioengineering (in press) 2009.

  • Namani R, Wood MD, Sakiyama-Elbert SE, Bayly PV. Anisotropic mechanical properties of magnetically aligned fibrin gels measured by magnetic resonance elastography. Journal of  Biomechanics; 42(13):2047-53, 2009.

  • Xie J, MacEwan MR, Li X, Sakiyama-Elbert SE, Xia Y. Neurite Outgrowth on Nanofiber Scaffolds with Different Orders, Structures, and Surface Properties. ACS Nano 3 (5), pp 1151–1159 (in press) 2009

  • Wood, MD, Moore, AM, Hunter, Mackinnon, SE, and Sakiyama-Elbert, SE. Heparin-Binding-Affinity-Based Delivery Systems Releasing Nerve Growth Factor Enhance Sciatic Nerve Regeneration. Journal of Biomaterials Science Polymer Edition (in press) 2009.

  • Thomopoulos S, Das R, Silva MJ, Sakiyama-Elbert S, Harwood FL, Zampiakis E, Kim HM, Amiel D, Gelberman RH. Enhanced flexor tendon healing through sustained delivery of PDGF-BB. Journal of Orthopaedic Research, (In Press), 2009.

  • Wood, MD, Moore, AM, Hunter, DA, Tuffaha, S, Borschel, GH, Mackinnon, SE, and Sakiyama-Elbert, SE. Affinity-based Release of Glial-Derived Neurotrophic Factor from Fibrin Matrices Enhances Sciatic Nerve Regeneration.  Acta Biomaterialia  5:959-68,  2009.

  • Johnson, PJ, Parker, SR, Sakiyama-Elbert, SE.  Fibrin-based tissue engineering scaffolds enhance neural fiber sprouting and delays the accumulation of reactive astrocytes at the lesion in a subacute model of spinal cord injury.  Journal of Biomedical Materials Research (in press), 2008. 

  • Moore, NM, Sheppard, CL, Sakiyama-Elbert, SE.  Characterization of a Multifunctional PEG-Based Gene Delivery System Containing Nuclear Localization Signals and Endosomal Escape Peptides.  Acta Biomaterialia.  5:854-64., 2009.

  • Xie, J, Willerth, SM, LI, X Rader, A, MacEwan, MR, Gottlieb, DI, Sakiyama-Elbert, SE, and Xia, Y. The Differentiation of Embryonic Stem Cells Seeded on Electrospun Nanofibers into Neural Lineages. Biomaterials 30: 354-62, 2009.

  • Willerth, SM, and Sakiyama-Elbert, SE. Kinetic Analysis of Neurotrophin-3 Mediated Differentiation of Embryonic Stem Cells into Neurons Tissue Engineering (in press) 2008.

  • Moore, NM, Sheppard, CL, Barbour, TR, Sakiyama-Elbert, SE.  The Effect of Endosomal Escape Peptides on In Vitro Gene Delivery of Polyethylene Glycol - Based Vehicles.  Journal of Gene Medicine. 10: 1134-1149, 2008.

  • Willerth, SM, Rader; A, Sakiyama-Elbert, SE. The Effect of Controlled Growth Factor Delivery on Embryonic Stem Cell Differentiation Inside of Fibrin Scaffolds.  Stem Cell Research . 1: 205-218,  2008.  Pubmed Central

  • Sakiyama-Elbert S, Das R, Gelberman RH, Harwood F, Amiel D, Thomopoulos S. Controlled release kinetics and biologic activity of PDGF-BB for use in flexor tendon repair. Journal of Hand Surgery [American], 33:1548-57, 2008.

  •  Wood MD, Borschel GH, and Sakiyama-Elbert SE. Controlled release of glial-derived neurotrophic factor from fibrin matrices containing an affinity-based delivery system.  Journal of Biomedical Materials Research Part A 89A:909-918, 2008. 

  • Moore, NM, Barbour, TR, Sakiyama-Elbert, SE. Synthesis and Characterization of Four-Arm Poly (ethylene glycol) Based Gene Delivery Vehicles Coupled to Integrin and DNA Binding Peptides. Molecular Pharmaceutics 5:140-150, 2008. 

  • Willerth, SM, Faxel, TE, Gottlieb, D, and Sakiyama-Elbert, SE.  The Effects of Soluble Growth Factors on Embryonic Stem Cell Differentiation Inside of Fibrin Scaffolds.  Stem Cells 25(9):2235-2244, 2007.   Pubmed Central
  • Thomopoulos, S, Zaegel, M, Das, R, Harwood FL, Silva, MJ, Amiel, D, Sakiyama-Elbert,S, Gelberman, RH. A novel method for growth factor delivery in tendon repair: Enhanced healing through sustained delivery of PDGF-BB. Journal of Orthopaedic Research 25(10): 1358-1368, 2007.
  • Wood, MD and Sakiyama-Elbert, SE.  Release Rate Controls Biological Activity of Nerve Growth Factor Released from Fibrin Matrices Containing Affinity-Based Delivery Systems.  Journal of Biomedical Materials Research Part A 84:300-312, 2008.
  • Gelberman, RH, Thomopoulos, S, Sakiyama-Elbert, S, Das, R, Silva, M. The Early Effects of Sustained Platelet Derived Growth Factor Administration on the Functional and Structural Properties of Repaired Intrasynovial Flexor Tendons The Journal of Hand Surgery 32(3): 373-379,  2007. 
  • Schmieder, AH, Grabski, LE, Moore, NM, Dempsey, LA, Sakiyama-Elbert, SE. Development of Novel Poly(ethylene glycol) Based Vehicles for Gene Delivery. Biotechnology and Bioengineering  96(5): 967-976, 2007.
  • Willerth, SJ, Johnson, PJ, Maxwell, DJ, Parsons, SP, Sakiyama-Elbert, SE. Rationally Designed Peptides for Controlled Release of Nerve Growth Factor from Fibrin Matrices  Journal of Biomedical Materials Research Part A 80A(1):13-23, 2007.
  • Taylor, SJ and Sakiyama-Elbert, SE. Effect of Controlled Delivery of Neurotrophin-3 from Fibrin on Spinal Cord Injury in a Long Term Model.  Journal of Controlled Release 116:204-210, 2006. Pubmed Central
  • Willerth, SM, Arendas KJ, Gottlieb, DI, Sakiyama-Elbert, SE. Optimization of Fibrin Scaffolds for Differentiation of Murine Embryonic Stem Cells into Neural Lineage Cells. Biomaterials 27(36):5990-6003, 2006. Pubmed Central
  • Taylor, SJ Rosenzweig, ES, McDonald, JW, Sakiyama-Elbert, SE.  Controlled Delivery of Neurotrophin-3 from Fibrin Scaffolds Enhances Neural Fiber Sprouting After Spinal Cord Injury Model. Journal of Controlled Release 113:225-235, 2006. Pubmed Central
  • Maxwell, DJ, Hicks, BC, Parson, S, Sakiyama-Elbert, SE. "Development of Rationally Designed Affinity-based Drug Delivery Systems", Acta Biomaterialia 1:101-113, 2005.
  • Taylor, S.J., McDonald, J.W., and Sakiyama-Elbert, S.E. "Controlled release of neurotrophin-3 from fibrin gels for spinal cord injury", J Controlled Release, 98, 281-294, 2004.
  • Lee,A.C., Yu,V.M.,  Lowe, J.B., Brenner, M.J., Hunter, D.A., Mackinnon, S.E. and Sakiyama-Elbert, S.E., "Controlled release of nerve growth factor enhances sciatic nerve regeneration",Experimental Neurology  84:  295-303, 2003.
  • Zisch, A.H., Schenk, U., Schense, J.C., Sakiyama-Elbert, S.E., and Hubbell, J.A., "Covalently conjugated VEGF-fibrin matrices for endothelialization", J. Controlled Release, 72: 101-113, 2001.
  • Sakiyama-Elbert, S.E., Panitch, A and Hubbell, J.A., "Development of growth factor fusion proteins for cell-triggered drug delivery", FASEB Journal 15: 1300-1302, 2001.
  • Sakiyama-Elbert, S.E. and Hubbell, J.A., " Controlled release of nerve growth factor from a heparin-containing fibrin-based cell ingrowth matrix", J. Controlled Release, 69: 149-158, 2000.
  • Sakiyama-Elbert, S.E. and Hubbell, J.A., "Development of Fibrin Derivatives for Controlled Release of Heparin-Binding Growth Factors" J. Controlled Release, 65: 389-402, 2000.
  • Sakiyama, S.E. and Hubbell, J.A., "Heparin-binding Peptides Enhance Neurite Extension in Three Dimensional Fibrin Gels", FASEB Journal 13: 2214-2224, 1999.

Selected Review Articles

Note:  Free full text articles available via Pubmed Central links for NIH funded research.